scientific paper

Department of Medical, Oral and biotechnological Sciences, Unit of Clinical Molecular Biology and Predictive Medicine, University of Chieti.

The aim of this study is to find a correlation between the bacterial content associated with periodontal disease and the effect of a systemic dental treatment with a curcumin-enriched toothpaste.



Periodontal disease is an inflammatory disorder that affects the structures of supporting teeth, including the gingiva, periodontal ligament and alveolar bone, causing loss of connective tissue,
resorption of the alveolar bone and the formation of periodontal pockets.

Primarily, periodontal disease is associated with a cohort of pathogenic bacteria, which determine biofilm synthesis and the induction of a cariogenic state of the teeth.
Materials and methods. In this study XXX volunteer patients, aged between 21 and 59 years, average age 35.5 years were enrolled.

Based on the depth of the gingival pocket between 3 and 7 mm, the patients were divided into two groups: the first (XX patients) with deep pockets> 5 mm and the second (XX patients, 53.7%) <5 mm.

Pocket depth and probing bleeding were the clinical parameters measured for each patient. The samples taken were processed for microbiological analysis using Taq-Man absolute quantitative technique in real time (kit CEIVD – Meridol-Perio-Diagnostics).

Purpose of the research. The registered volunteers were randomly divided into two groups: X were treated with a regular toothpaste (Vitalex * formula, toothpaste enriched with herbs and natural flavors,
* registered trademark) and other Xs were treated with Vitalex curcumin-enriched toothpaste two weeks of dispensing two treatments a day (one in the morning and the other in the evening). On day 0 before treatment, an extract of plaque content from the deep gingival pocket was taken and processed for DNA extraction and real-time PCR analysis of periodontal pathogenic bacteria. The same procedure was applied at the end of the treatment. The evaluation of the data was based on the quantitative presence of bacterial species investigated.


Patients treated with the two toothpaste preparations were analyzed as quantitative presence of periodontal bacteria in their deep gum pocket and dental plaque.



The volunteers after curcumin-enriched toothpaste showed a significant reduction in the amount of periodontal pathogens present in their gum pocket.

This preliminary pilot study suggests that curcumin dissolved in toothpaste gives a potential beneficial effect on lowering the content of pathogenic bacteria, causing a decrease in cariogenic promotion and giving a beneficial antiinflammatory state, counteracting periodontal disease.

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